low frequencies – Communicable Diseases Research

Host-pathogen dynamics in longitudinal clinical specimens from patients with COVID-19

COVID-19 환자의 종단 임상 표본에서 숙주-병원체 역학

Article

Published on 2022-04-072022-09-11
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법,

SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection

감염성이 감소하고 BNT162B2 백신에 대한 감도가 다양한 SARS-COV-2 변이체가 감염 과정에서 개발됩니다.

Clinical Trial

Published on 2022-01-122022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, 변종, 임상, 치료기술, 치료법,

[키워드] addition Affect Analysis analyzed Anti-spike Antibody neutralization antibody neutralization activity Author BNT162b2 BNT162b2 vaccine circulating convalescent plasma Course COVID-19 vaccine COVID-19 vaccines demonstrated elicit employment Evolution Frequency highlight Host human host human population impair in-depth analysis increase in individual infected individual infected individuals Infection infectivity capacity intra-host SARS-CoV-2 variant intra-host SARS-CoV-2 variants Intra-host variant intra-host variants L1197I mutation landscape less low frequencies mRNA mRNA-based mutated mutated variant mutated variants N gene N genes natural infection neutralization Neutralizing antibodies nose-throat swab nose-throat swabs pandemic plasma plasma neutralization activity platform Point mutation potential circulating variants Protective Quasispecies quasispecy raised reduced respiratory Respiratory system S gene S2 subunit SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 intra-host variability SARS-CoV-2 intra-host variant SARS-CoV-2 intra-host variants SARS-CoV-2 mutagenesis SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing Sequencing database Sequencing databases single-genome sequencing Spike protein Spike proteins spike variant Spread swab sample swab samples the SARS-CoV-2 the spike protein vaccinated individuals vaccination rate variant variants variants of concern
[DOI] 10.1371/journal.ppat.1010242 PMC 바로가기 [Article Type] Clinical Trial

Evaluation of the “safe multidisciplinary app-assisted remote patient-self-testing (SMART) model” for warfarin home management during the COVID-19 pandemic: study protocol of a multi-center randomized controlled trial

COVID-19 Pandemic 동안 Warfarin Home Management를위한 "안전한 다 분야 앱 보조 원격 환자-테스트 (SMART) 모델"평가 : 다중 센터 무작위 대조 시험의 연구 프로토콜

Study Protocol

Published on 2021-08-262022-09-10
Journal: BMC health services research
[Category] MERS, SARS, 임상,

[키워드] adjust All the patient all the patients anticoagulation applied assigned bleeding China chronic disease Clinical outcome clinics Complication complications Control control group control groups cost-effectiveness country COVID-19 COVID-19 pandemic demonstrated develop dosage Dosing Effectiveness Eligible patients Evidence Follow-up Frequency healthcare hospital hospitals implementation incidence INR International international normalized ratio issue life low frequencies major bleeding management normalized Patient Patient self-testing point-of-care problem Quality of life Randomized controlled trial Randomly receive reduced remote resulting Safety Study protocol therapeutic therapeutic range thromboembolic Thromboembolic event Thromboembolic events Treatment Trial registration TTR Usage usual care Warfarin while
[DOI] 10.1186/s12913-021-06882-7 PMC 바로가기 [Article Type] Study Protocol

SARS-CoV-2 variant evolution in the United States: High accumulation of viral mutations over time likely through serial Founder Events and mutational bursts

SARS-COV-2 변이체 진화 미국에서 : 연쇄 창립자 사건 및 돌연변이 버스트를 통해 시간이 지남에 따라 바이러스 돌연변이의 높은 축적

Research Article

Published on 2021-07-232022-09-10
Journal: PLoS ONE
[Category] MERS, SARS, 변종, 치료기술,

[키워드] accumulating additional Spike mutations Amino acid amino acid change amino acid changes B.1.1.7 burst caused Cohort Combination concerning COVID-19 death enzyme Evolution Evolution of SARS-CoV-2 Frequency furin furin cleavage site Genome Glutamine Infection Lineage low frequencies low frequency Mutation mutations nucleotide pandemic pattern predominant Prevalence prominence Protein quartile residue RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variant sequence sequences single nucleotide variation single nucleotide variations SNVs spike Spike protein Spread summer super-spreader events the SARS-CoV-2 genome the Spike The United States United States vaccine platform variant variants of concern Variation Viral viral genome viral genomes viral isolates viral mutation Wuhan Wuhan, China
[DOI] 10.1371/journal.pone.0255169 PMC 바로가기 [Article Type] Research Article

Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts

감염된 숙주 내 및 전체에 걸친 SARS-CoV-2 돌연변이 축적의 시간적 역학

Research Article

Published on 2021-04-072022-08-13
Journal: PLoS Pathogens
[Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] accumulate can not chance Cluster Cohort collected Community Consensus consensus sequence consensus sequences convergent evolution Coverage Critical defined determine Epidemic Epidemiology Evolution Frequency genetic diversity Genetic variant Genome sequencing genomes help high resolution hospitalized COVID-19 patient hospitalized COVID-19 patients Host identify identifying individual Infection investigated lineages low frequencies Metadata MONITOR Mutation Outbreaks Prevent Public health intervention Public health interventions reflect RNA SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 mutation SARS-CoV-2 transmission sequence sequenced Sequencing single medical center specimen Spread Strains symptom onset Temporal Transmission transmission of SARS-CoV-2 understanding unlikely utility variant variants Variation Viral Viral genome sequencing Viral load viral variant
[DOI] 10.1371/journal.ppat.1009499 PMC 바로가기 [Article Type] Research Article

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

SARS-CoV-2 스파이크 단백질 변이체에 의한 중화 항체로부터의 탈출

Research Article

Published on 2020-10-282022-09-10
Journal: eLife
[Category] MERS, SARS, 변종, 진단,

[키워드] activate addressed Administered Analysis anti-SARS-CoV-2 antibodies antibody antibody combination antibody-based therapies antibody-based therapy Blood blood plasma cause Cell cells changed chimeric circulating Combination convalescent plasma coronavirus COVID-19 COVID19 creating effective vaccine Effective vaccines Effectiveness effort elicited eLife Epitopes escape evade Frequency functional Genome Health HIV host cells Human human cells human population human populations immune immune response immune system in some individual infect Infection Influenza kill Laboratory limit low frequencies maintain monoclonal antibodies monoclonal antibody mutant mutant virus mutate mutated Mutation N-terminal domain natural infection neutralize Neutralizing antibodies neutralizing antibody neutralizing epitopes New coronavirus Patient Population populations Prevent produced Prophylactic Proteins question RBD Receptor-binding domain Recovered COVID-19 patients reporter Research SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS-CoV-2 variant selected Sequencing Spike protein Spike proteins Structure structures target the antibody the disease the receptor-binding domain the SARS-CoV-2 the spike protein the strongest therapeutic Therapies treated Trigger vaccination Vaccine Vaccines variant Viral protein Viral proteins virus virus virus mutation virus particle virus particles viruses VSV were infected
[DOI] 10.7554/eLife.61312 PMC 바로가기 [Article Type] Research Article

Extensive Copy-Number Variation of Young Genes across Stickleback Populations

스틱백 개체군에 걸친 젊은 유전자의 광범위한 복사 수 변이

Research Article

Published on 2014-12-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] adaptive analysis candidate Candidates category CNV CNV gene CNV genes CNVs Comparative genomics complexity copy-number variation copy-number variations disparate distribution duplicate gene Duplicate genes duplication duplications eco-genomic model ecological Effect elevated evaluate Evolution Extensive fixed Frequency function functional Genes Genetic genetic diversity Genome highlight identify individual Innovation interactions joint lineage-specific gene lineage-specific genes Local locus low frequencies molecular natural populations occur over Population population genomics population level populations prevalent producing selective pressure selective pressures Stage structural polymorphism subset teleost genome teleost genomes three-spined stickleback three-spined sticklebacks Variation whole genome sequence
[DOI] 10.1371/journal.pgen.1004830 PMC 바로가기 [Article Type] Research Article

Field-Caught Permethrin-Resistant Anopheles gambiae Overexpress CYP6P3, a P450 That Metabolises Pyrethroids

현장에서 포착된 퍼메트린 내성 Anopheles gambiae CYP6P3, 피레스로이드를 대사하는 P450 과발현

Research Article

Published on 2008-11-282022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] A. gambiae adaptive adaptive mechanism adaptive mechanisms Alpha alpha-cyano Anopheles gambiae anopheline mosquitoes Author bioassays compounds Critical CYP6P3 cytochrome P450 detect disease spread Efficacy ENCODE enzyme Enzymes Evolution facilitate found Frequency Gene Gene Expression Genetic Health health problem identify individual insect insecticide insecticides Insects involved lead low frequencies malaria malaria vector malaria vector control mechanism Messenger RNA Metabolic resistance metabolise Molecular assay molecular mechanism molecular mechanisms MONITOR natural selection overexpressed P450 pesticide pesticides phenotyped populations public health pyrethroid Pyrethroids receiving recessive allele reducing resistance significantly sub-Saharan Africa Survivors sustainability trait transcript level translated Transmission undergo
[DOI] 10.1371/journal.pgen.1000286 PMC 바로가기 [Article Type] Research Article